The Bills are 9-2, their best start since 1992, and with a win would clinch their fifth straight AFC East title.

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

San Francisco 49ers head coach Kyle Shanahan spoke with reporters via a conference call on Monday, providing several injury updates following the team's 38-10 loss to the Green Bay Packers. ...

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

The San Francisco 49ers and Buffalo Bills are set to face-off in the Week 13 edition of Sunday Night Football. Before the season began, this matchup was circled ...

Three things I’m pondering as the Bills return from their bye for the stretch run… Mila-No More Waiting Matt Milano is ...

Brock Purdy revealed what he thought about while standing on the sideline at the of the San Francisco 49ers' loss to the ...

Indianapolis Colts (5-7) at New England Patriots (3-9), 8 a.m. HST, CBS ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

As for Purdy’s supporting cast, it will be without some key players. The 49ers will be missing the left side of their ...

Brock Purdy will make his return from a shoulder injury this Sunday when the 49ers face the Buffalo Bills. On Friday, Purdy spoke to the media for the first tim ...