KenPom, the gold standard college basketball analytical site, rates Duke as a four-point favorite in this neutral-court matchup. It also has Duke ranked fourth and Kansas at No. 9. It could be wise, though, to go against the grain in this one as money begins to come in on Kansas as we get closer to game time.

The No. 1 Kansas Jayhawks proved to be too much for Cooper Flagg and the Duke Blue Devils. On Tuesday, Duke basketball tasted its second defeat of the season, as the ACC powerhouse fell prey to Bill Self’s Jayhawks via a score of 75-72 at T-Mobile Arena in Las Vegas.

The Duke Blue Devils get to play a role the five-time national champions aren't accustomed to on Tuesday night: the underdo

The No. 1 Kansas Jayhawks take on the No. 12 Duke Blue Devils at T-Mobile Arena in Las Vegas, Nevada. Tuesday's matchup is the first of the season for the teams.

With another big-time game coming up for Duke Tuesday against top-ranked Kansas, the Blue Zone breaks down the matchup with an overview, key stat, x-factor and three keys to a Blue Devil victory:

For the second time this young season, No. 11 Duke fell to a ranked opponent after squandering scoring chances late in the fourth quarter, losing to No. 1 Kansas in Las Vegas.

Experience is key for Duke basketball as the Blue Devils try to become the best version of themselves by March. Kansas provided the latest lesson.

The Duke Blue Devils clawed back from an early hole against the No. 1 Kansas Jayhawks on Tuesday night, but freshman superstar Cooper Flagg and his teammates couldn't close the deal on a trajectory-changing upset.